KNAW Repository

Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth

Hol, W.H.G. and Van Veen, J.A. (2002) Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth. Journal of Chemical Ecology, 28, 1763-1772. ISSN 0098-0331.

[img]PDF - Published Version
Restricted to KNAW only


Official URL:


We investigated the growth-reducing effects of pyrrolizidine alkaloids (PAs) from Senecio jacobaea on nine plant-associated fungi (five strains of Fusarium oxysporum, two of F. sambucinum, and two of Trichoderma sp). Fungal growth was monitored on water agar media containing different concentrations of monocrotaline, retrorsine, or a purified extract of PAs from S. jacobaea. The growth rate of six strains was inhibited by PAs at the highest test concentration (3.33 mM), with the magnitude of the inhibition (7-35%) being dependent upon the specific fungus-PA interaction. In general, the PA extract caused the largest inhibition. However, the fungi isolated from S. jacobaea were positively affected by the PA extract (7-9%). Retrorsine N oxide was as effective as retrorsine in its inhibition of mycelium growth. [KEYWORDS: Senecio jacobaea, pyrrolizidine alkaloids, anti fungal activity, retrorsine, N oxide, monocrotaline]

Item Type:Article
Institutes:Nederlands Instituut voor Ecologie (NIOO)
ID Code:11160
Deposited On:24 Nov 2011 01:00
Last Modified:31 Mar 2014 10:28

Repository Staff Only: item control page