KNAW Repository

Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii

Bovers, M. and Hagen, F. and Kuramae, E.E. and Diaz, M.R. and Spanjaard, L. and Dromer, F. and Hoogveld, H.L. and Boekhout, T. (2006) Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii. FEMS Yeast Research, 6, 599-607. ISSN 1567-1356.

[img]PDF - Published Version
Restricted to KNAW only

862Kb

Official URL: http://dx.doi.org/10.1111/j.1567-1364.2006.00082.x

Abstract

Cryptococcus neoformans and Cryptococcus gattii are yeasts that cause meningoencephalitis, but that differ in host range and geographical distribution. Cryptococcus neoformans occurs world-wide and mostly infects immunocompromised patients, whereas C. gattii occurs mainly in (sub)tropical regions and infects healthy individuals. Anomalous C. neoformans strains were isolated from patients. These strains were found to be monokaryotic, and diploid or aneuploid. Amplified Fragment Length Polymorphism (AFLP) and sequence analyses indicated that AFLP genotypes 2 (C. neoformans) and 4 (C. gattii) were present. The strains were serologically BD. Mating- and serotype-specific PCR reactions showed that the strains were MATa-serotype D/MATa-serotype B. This study is the first to describe naturally occurring hybrids between C. neoformans and C. gattii. [KEYWORDS: Cryptococcus neoformans ; Cryptococcus gattii ; BD hybrid ; recurrent meningitis]

Item Type:Article
Institutes:Nederlands Instituut voor Ecologie (NIOO)
Centraalbureau voor Schimmelcultures (CBS)
ID Code:11915
Deposited On:16 Nov 2011 01:00
Last Modified:31 Mar 2014 10:40

Repository Staff Only: item control page