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Unlocking the potential of metagenomics through replicated experimental design

Knight, R. and Jansson, J. and Field, D. and Fierer, N. and Desai, N. and Fuhrman, J.A. and Hugenholtz, P. and Van der Lelie, D. and Meyer, F. and Stevens, R. and Bailey, M.J. and Gordon, J.I. and Kowalchuk, G.A. and Gilbert, J.A. (2012) Unlocking the potential of metagenomics through replicated experimental design. Nature Biotechnology, 30, 513-520. ISSN 1087-0156.

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Metagenomics holds enormous promise for discovering novel enzymes and organisms that are biomarkers or drivers of processes relevant to disease, industry and the environment. In the past two years, we have seen a paradigm shift in metagenomics to the application of cross-sectional and longitudinal studies enabled by advances in DNA sequencing and high-performance computing. These technologies now make it possible to broadly assess microbial diversity and function, allowing systematic investigation of the largely unexplored frontier of microbial life. To achieve this aim, the global scientific community must collaborate and agree upon common objectives and data standards to enable comparative research across the Earth's microbiome. Improvements in comparability of data will facilitate the study of biotechnologically relevant processes, such as bioprospecting for new glycoside hydrolases or identifying novel energy sources.

Item Type:Article
Institutes:Nederlands Instituut voor Ecologie (NIOO)
ID Code:12464
Deposited On:05 Jul 2012 02:00
Last Modified:28 Nov 2013 12:59

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