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Wnt/beta-catenin signaling in development and disease.

Clevers, J.C. (2006) Wnt/beta-catenin signaling in development and disease. Cell, 127(3), 469-480. ISSN 00928674. doi: 10.1016/j.cell.2006.10.018.

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A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.

Item Type:Article
Additional Information:doi: 10.1016/j.cell.2006.10.018
Institutes:Hubrecht Instituut
ID Code:3589
Deposited On:13 Feb 2009 17:14
Last Modified:10 Dec 2009 13:14

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