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Wnt signaling in the intestinal epithelium: from endoderm to cancer.

Gregorieff, A. and Clevers, J.C. (2005) Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes & development, 19(8), 877-890. ISSN 08909369. doi: 10.1101/gad.1295405.

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Abstract

The Wnt pathway controls cell fate during embryonic development. It also persists as a key regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational deregulation of the Wnt cascade is closely associated with malignant transformation. The intestinal epithelium represents the best-understood example for the closely linked roles of Wnt signaling in homeostatic self-renewal and malignant transformation. In this review, we outline current understanding of the physiological role of Wnt signaling in intestinal biology. From this perspective, we then describe how mutational subversion of the Wnt cascade leads to colorectal cancer.

Item Type:Article
Additional Information:doi: 10.1101/gad.1295405
Institutes:Hubrecht Instituut
ID Code:3613
Deposited On:13 Feb 2009 17:14
Last Modified:10 Dec 2009 13:14

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