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Self-renewal and cancer of the gut: two sides of a coin.

Radtke, F. and Clevers, J.C. (2005) Self-renewal and cancer of the gut: two sides of a coin. Science, 307(5717), 1904-1909. ISSN 10959203. doi: 10.1126/science.1104815.

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The intestinal epithelium follows the paradigms of stem cell biology established for other self-renewing tissues. With a unique topology, it constitutes a two-dimensional structure folded into valleys and hills: the proliferative crypts and the differentiated villi. Its unprecedented self-renewal rate appears reflected in a high susceptibility to malignant transformation. The molecular mechanisms that control homeostatic self-renewal and those that underlie colorectal cancer are remarkably symmetrical. Here, we discuss the biology of the intestinal epithelium, emphasizing the roles played by Wnt, bone morphogenic protein, and Notch signaling cascades in epithelial self-renewal and cancer.

Item Type:Article
Additional Information:doi: 10.1126/science.1104815
Institutes:Hubrecht Instituut
ID Code:3616
Deposited On:13 Feb 2009 17:14
Last Modified:10 Dec 2009 13:14

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