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FoxM1 is required for execution of the mitotic programme and chromosome stability.

Laoukili, J. and Kooistra, M.R.H. and Bras, A. and Kauw, J. and Kerkhoven, R.M. and Morrison, A. and Clevers, J.C. and Medema, R.H. (2005) FoxM1 is required for execution of the mitotic programme and chromosome stability. Nature cell biology, 7(2), 126-136. ISSN 14657392. doi: 10.1038/ncb1217.

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Abstract

Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of subsequent cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 regulates expression of many G2-specific genes and is essential for chromosome stability. Loss of FoxM1 leads to pleiotropic cell-cycle defects, including a delay in G2, chromosome mis-segregation and frequent failure of cytokinesis. We show that transcriptional activation of cyclin B by FoxM1 is essential for timely mitotic entry, whereas CENP-F, another direct target of FoxM1 identified here, is essential for precise functioning of the mitotic spindle checkpoint. Thus, our data uncover a transcriptional cluster regulated by FoxM1 that is essential for proper mitotic progression.

Item Type:Article
Additional Information:doi: 10.1038/ncb1217
Institutes:Hubrecht Instituut
ID Code:3620
Deposited On:13 Feb 2009 17:14
Last Modified:10 Dec 2009 13:14

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