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WNT signalling and haematopoiesis: a WNT-WNT situation.

Staal, F.J.T. and Clevers, J.C. (2005) WNT signalling and haematopoiesis: a WNT-WNT situation. Nature reviews. Immunology, 5(1), 21-30. ISSN 14741733. doi: 10.1038/nri1529.

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Abstract

The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

Item Type:Article
Additional Information:doi: 10.1038/nri1529
Institutes:Hubrecht Instituut
ID Code:3621
Deposited On:13 Feb 2009 17:14
Last Modified:10 Dec 2009 13:14

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