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Immunohistochemical screening for autoantibodies against lateral hypothalamic neurons in human narcolepsy.

Overeem, S. and Verschuuren, J.J. and Fronczek, R. and Schreurs, L. and Hertog, H. den and Hegeman-Kleinn, I.M. and Duinen, S.G. van and Unmehopa, U.A. and Swaab, D.F. and Lammers, G.J. (2006) Immunohistochemical screening for autoantibodies against lateral hypothalamic neurons in human narcolepsy. Journal of neuroimmunology, 174(1-2), 187-192. ISSN 01655728. doi: 10.1016/j.jneuroim.2006.02.010.

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Abstract

Most human patients with narcolepsy have no detectable hypocretin-1 in their cerebrospinal fluid. The cause of this hypocretin deficiency is unknown, but the prevailing hypothesis states that an autoimmune-mediated mechanism is responsible. We screened for the presence of autoantibodies against neurons in the lateral hypothalamus in 76 patients and 63 controls, using immunohistochemistry. Autoantibodies were present in two patients, but also in two controls. However, one of the patients had a clearly different staining pattern and nerve endings of immunolabeled cells were found to project onto hypocretin-producing neurons, suggesting a possible pathophysiological role. Humoral immune mechanisms appear not to play a role in the pathogenesis of narcolepsy, at least not in the clinically overt stage of the disease.

Item Type:Article
Additional Information:doi: 10.1016/j.jneuroim.2006.02.010
Institutes:Netherlands Institute for Neuroscience (NIN)
ID Code:3705
Deposited On:13 Feb 2009 17:14
Last Modified:10 Dec 2009 13:14

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