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Increased melanin concentrating hormone receptor type I in the human hypothalamic infundibular nucleus in cachexia.

Unmehopa, U.A. and Heerikhuize, J.J. van and Spijkstra, W. and Woods, J.W. and Howard, A.D. and Zycband, E. and Feighner, S.D. and Hreniuk, D.L. and Palyha, O.C. and Guan, X.-M. and MacNeil, D.J. and Ploeg, L.H.T. and Swaab, D.F. (2005) Increased melanin concentrating hormone receptor type I in the human hypothalamic infundibular nucleus in cachexia. The Journal of clinical endocrinology and metabolism, 90(4), 2412-2419. ISSN 0021972X. doi: 10.1210/jc.2004-1145.

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Abstract

Melanin-concentrating hormone (MCH) exerts a positive regulation on appetite and binds to the G protein-coupled receptors, MCH1R and MCH2R. In rodents, MCH is produced by neurons in the lateral hypothalamus with projections to various hypothalamic and other brain sites. In the present study, MCH1R was shown, by immunocytochemistry, to be present in the human infundibular nucleus/median eminence, paraventricular nucleus, lateral hypothalamic area, and perifornical area, although in the latter two regions, only a few MCH1R-containing cells were found. In addition, MCH1R staining was found in nerve fibers in the periventricular nucleus, dorsomedial and ventromedial nucleus, suprachiasmatic nucleus, and tuberomammillary nucleus. A significant 1.6 times increase in the number of MCH1R cell body staining was found in the infundibular nucleus in postmortem brain material of cachectic patients, compared with matched controls, supporting a role for this receptor in energy homeostasis in the human.

Item Type:Article
Additional Information:doi: 10.1210/jc.2004-1145
Institutes:Netherlands Institute for Neuroscience (NIN)
ID Code:3726
Deposited On:13 Feb 2009 17:14
Last Modified:10 Dec 2009 13:14

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