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Use of specified tcf target genes to identify drugs for the treatment of cancer in particular colorectal cancer in which tcf/ss-cateini/wnt signalling plays a central role

Colland, F. and Barker, N. and Clevers, J.C. and Gomez, E. and Lambertus, M. and Suils, E.S. (2006) Use of specified tcf target genes to identify drugs for the treatment of cancer in particular colorectal cancer in which tcf/ss-cateini/wnt signalling plays a central role. United States Patent 20060165699; http://www.freepatentsonline.com/20060165699.html.

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Abstract

The present invention relates to the use of inhibitors of the expressed proteins of TCF target genes whose expression is regulated by TCF/.beta.-catenin complexes for the preparation of a therapeutical composition for the treatment of cancers in which TCF/.beta.-catenin signalling is deregulated. Such inhibitors can be antibodies, small molecules, antisense RNA and dsRNA for use in RNAi. The invention also relates to these inhibitors per se.

Item Type:Patent
Additional Information:United States Patent 20060165699; http://www.freepatentsonline.com/20060165699.html
Institutes:Hubrecht Instituut
ID Code:3771
Deposited On:13 Feb 2009 17:14
Last Modified:10 Dec 2009 13:14

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