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Retinal vessel diameters and the role of inflammation in cerebrovascular disease

Jong, F.J. and Ikram, M.K. and Witteman, J.C. and Hofman, A. and Jong de, P.T.V.M. and Breteler, M.M. (2007) Retinal vessel diameters and the role of inflammation in cerebrovascular disease. Annals of Neurology, 61(5), 491-495. doi:10.1002/ana.21129.

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Abstract

Retinal vessels may provide a way to study the cerebral microcirculation. In particular, larger retinal venular diameters have been associated with cerebrovascular disease. An inflammatory response may underlie this association. In a population-based cohort study among 5,279 participants aged 55 years or older with graded retinal vessel diameters, we observed that greater serum levels of C-reactive protein and fibrinogen and greater lipoprotein-associated phospholipase A(2) activity were strongly associated with larger venular diameters. Weaker associations were found with arteriolar diameters. Our findings support the hypothesis that larger retinal venular diameters reflect systemic inflammation and suggest that inflammation is involved in cerebrovascular disease.

Item Type:Article
Additional Information:doi:10.1002/ana.21129
Institutes:Netherlands Institute for Neuroscience (NIN)
ID Code:3785
Deposited On:13 Feb 2009 17:14
Last Modified:10 Dec 2009 13:14

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