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Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole

Bonifaz, A. and Hoog de, G.S. and McGinnis, M.R. and Saul, A and Rodriguez-Cortes, O. and Araiza, J. and Cruz, M.A. and Mercadillo, P. (2009) Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole. Medical Mycology, 47, 111-114. ISSN 1369-3786.

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A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012g/ml.

Item Type:Article
Institutes:Centraalbureau voor Schimmelcultures (CBS)
ID Code:6853
Deposited On:27 Jan 2010 01:00
Last Modified:03 Aug 2010 15:25

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