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Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation.

Guryev, V. and Cuppen, E.P.J.G. (2009) Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation. FEBS Letters, 583, 1668-73. ISSN 0014-5793.

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Abstract

Rapid advances in DNA sequencing improve existing techniques and enable new approaches in genetics and functional genomics, bringing about unprecedented coverage, resolution and sensitivity. Enhanced toolsets can facilitate the untangling of connections between genomic variation, environmental factors and phenotypic effects, providing novel opportunities, but may also pose challenges in data interpretation, especially in highly heterogeneous human populations. Laboratory rodent strains, however, offer a variety of tailored model systems with controlled genetic backgrounds, facilitating complex genotype/phenotype relationship studies. In this review we discuss the advent of massively parallel sequencing, its methodological advantage for molecular analysis in model organisms and the expectation of increased understanding of biologically relevant consequences of human genetic variation.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:6944
Deposited On:15 Dec 2009 01:00
Last Modified:13 Oct 2010 12:51

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