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Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.

Young, T. and Rowland, J.E. and Ven van de, C. and Bialecka, M. and Novoa, A. and Carapuco, M. and Nes van, J. and Graaff de, W.G.A.J. and Duluc, I. and Freund, J.N. and Beck, F. and Mallo, M. and Deschamps, J.T.G. (2009) Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Developmental Cell, 17, 516-26. ISSN 1534-5807.

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Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis, and caudal urorectal structures. We show that trunk Hox genes stimulate axial extension, as they can largely rescue these Cdx mutant phenotypes. Conversely, posterior (paralog group 13) Hox genes can prematurely arrest posterior axial growth when precociously expressed. Our data suggest that the transition from trunk to tail Hox gene expression successively regulates the construction and termination of axial structures in the mouse embryo. Thus, Hox genes seem to differentially orchestrate posterior expansion of embryonic tissues during axial morphogenesis as an integral part of their function in specifying head-to-tail identity. In addition, we present evidence that Cdx and Hox transcription factors exert these effects by controlling Wnt signaling. Concomitant regulation of Cyp26a1 expression, restraining retinoic acid signaling away from the posterior growth zone, may likewise play a role in timing the trunk-tail transition.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:6946
Deposited On:15 Dec 2009 01:00
Last Modified:13 Oct 2010 12:51

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