KNAW Repository

Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling.

Tee, J.M. and Rooijen van, C.R. and Boonen, R.A.C.M. and Zivkovic, D. (2009) Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS One, 4. ISSN 1932-6203.

Full text not available from this repository.

Abstract

Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effects of Wnt/beta-catenin signaling on fast muscle hypertrophy were rescued by misexpression of Myostatin or p21(CIP/WAF), establishing an in vivo regulation of myofibrillogenesis by Wnt/beta-catenin signaling and Myostatin. Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:6962
Deposited On:24 Dec 2009 01:00
Last Modified:13 Oct 2010 12:51

Repository Staff Only: item control page