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Apc1-mediated antagonism of Wnt/beta-catenin signaling is required for retino-tectal pathfinding in the zebrafish.

Paridaen, J.T.M. and Danesin, C. and Elas, A.T. and Water van de, S.G.P. and Houart, C. and Zivkovic, D. (2009) Apc1-mediated antagonism of Wnt/beta-catenin signaling is required for retino-tectal pathfinding in the zebrafish. Zebrafish, 6, 41-7. ISSN 1557-8542.

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Abstract

The tumor suppressor Apc1 is an intracellular antagonist of the Wnt/beta-catenin pathway. We examined the effects of an Apc1 loss-of-function mutation on retino-tectal axon pathfinding in zebrafish. In apc mutants, the retina is disorganized and optic nerves portray pathfinding defects at the optic chiasm and do not project properly to the tectum. Wild-type cells, transplanted into mutant retinae, acquire retinal ganglion cell fate and project axons that cross at the mispositioned optic chiasm and extend to the contralateral tectum, suggesting a function of apc1 in axon pathfinding. These defects are caused mainly by stabilization of beta-catenin. These data demonstrate that Apc1 function is required for correct patterning of the retina and proper retinal ganglion axon projections.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:6964
Deposited On:24 Dec 2009 01:00
Last Modified:13 Oct 2010 12:51

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