Hogan, B.M. and Bos, F. L. and Bussmann, J. and Witte de, M. and Chi, N. C. and Duckers, H.J. and Schulte-Merker, S. (2009) Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nature Genetics, 41, 396-8. ISSN 1061-4036.
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Official URL: http://dx.doi.org/10.1038/ng.321
Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.
|Deposited On:||25 Jan 2010 01:00|
|Last Modified:||13 Oct 2010 12:51|
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