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Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Hogan, B.M. and Bos, F. L. and Bussmann, J. and Witte de, M. and Chi, N. C. and Duckers, H.J. and Schulte-Merker, S. (2009) Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nature Genetics, 41, 396-8. ISSN 1061-4036.

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Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:6986
Deposited On:25 Jan 2010 01:00
Last Modified:13 Oct 2010 12:51

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