Homberg, J.R. and Fleur la, S. E. and Cuppen, E.P.J.G. (2009) Serotonin Transporter Deficiency Increases Abdominal Fat in Female, but Not Male Rats. Obesity. ISSN 1930-7381.
Full text not available from this repository.
Official URL: http://dx.doi.org/10.1038/oby.2009.139
Depression and abdominal obesity often co-occur, predominantly in women, and are associated with an increased risk for the development of glucose intolerance and subsequently type 2 diabetes. The underlying mechanisms are poorly understood. We found that female, but not male, depression-prone serotonin transporter knockout (SERT(-/-)) rats had a strong increase (54%) in abdominal fat, whereas no increases in plasma concentrations of glucose and insulin were observed. Surprisingly, application of a high-fat, high-sucrose (HFHS)-choice diet, which results in increased abdominal fat deposition and increased plasma glucose levels in wild-type rats, did not result in elevated plasma glucose levels in female SERT(-/-) rats. Our results show that serotonin transporter deficiency affects abdominal fat deposition in a sex-dependent way, but protects against rises in glucose levels, and thereby potentially glucose intolerance. The increased abdominal fat formation could result from serotonin-mediated developmental changes and provides heuristic value for understanding the effects of the depression-associated serotonin transporter promoter polymorphism in humans.Obesity (2009) doi:10.1038/oby.2009.139.
|Deposited On:||25 Jan 2010 01:00|
|Last Modified:||13 Oct 2010 12:51|
Repository Staff Only: item control page