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Serotonin Transporter Deficiency Increases Abdominal Fat in Female, but Not Male Rats

Homberg, J.R. and Fleur la, S. E. and Cuppen, E.P.J.G. (2009) Serotonin Transporter Deficiency Increases Abdominal Fat in Female, but Not Male Rats. Obesity. ISSN 1930-7381.

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Depression and abdominal obesity often co-occur, predominantly in women, and are associated with an increased risk for the development of glucose intolerance and subsequently type 2 diabetes. The underlying mechanisms are poorly understood. We found that female, but not male, depression-prone serotonin transporter knockout (SERT(-/-)) rats had a strong increase (54%) in abdominal fat, whereas no increases in plasma concentrations of glucose and insulin were observed. Surprisingly, application of a high-fat, high-sucrose (HFHS)-choice diet, which results in increased abdominal fat deposition and increased plasma glucose levels in wild-type rats, did not result in elevated plasma glucose levels in female SERT(-/-) rats. Our results show that serotonin transporter deficiency affects abdominal fat deposition in a sex-dependent way, but protects against rises in glucose levels, and thereby potentially glucose intolerance. The increased abdominal fat formation could result from serotonin-mediated developmental changes and provides heuristic value for understanding the effects of the depression-associated serotonin transporter promoter polymorphism in humans.Obesity (2009) doi:10.1038/oby.2009.139.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:6987
Deposited On:25 Jan 2010 01:00
Last Modified:13 Oct 2010 12:51

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