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Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration

Matondo, R. B. and Punt, C. and Homberg, J.R. and Toussaint, M. J. and Kisjes, R. and Korporaal, S. J. and Akkerman, J. W. and Cuppen, E.P.J.G. and Bruin de, A. (2009) Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration. American journal of physiology. Gastrointestinal and liver physiology, 296, G963-8. ISSN 0193-1857.

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Official URL: http://dx.doi.org/10.1152/ajpgi.90709.2008

Abstract

The serotonin transporter is implicated in the uptake of the vasoconstrictor serotonin from the circulation into the platelets, where 95% of all blood serotonin is stored and released in response to vascular injury. In vivo studies indicated that platelet-derived serotonin mediates liver regeneration after partial hepatectomy. We have recently generated serotonin transporter knockout rats and demonstrated that their platelets were almost completely depleted of serotonin. Here we show that these rats exhibit impaired hemostasis and contain about 1-6% of wild-type serotonin levels in the blood. Despite the marked reduction of serotonin levels in blood and platelets, efficient liver regeneration and collagen-induced platelet aggregation occur in rats lacking the serotonin transporter. These results provide evidence that liver regeneration is not dependent on the release of serotonin from platelets. Our findings indicate that very low levels of serotonin in blood are sufficient for liver regeneration.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:7022
Deposited On:29 Jan 2010 01:00
Last Modified:13 Oct 2010 12:52

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