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Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells

Barker, N. and Clevers, H. (2010) Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology, 138, 1681-96. ISSN 0016-5085.

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Official URL: http://dx.doi.org/10.1053/j.gastro.2010.03.002

Abstract

Molecular markers are used to characterize and track adult stem cells. Colon cancer research has led to the identification of 2 related receptors, leucine-rich repeat-containing, G-protein-coupled receptors (Lgr)5 and Lgr6, that are expressed by small populations of cells in a variety of adult organs. Genetic mouse models have allowed the visualization, isolation, and genetic marking of Lgr5(+ve) and Lgr6(+ve) cells and provided evidence that they are stem cells. The Lgr5(+ve) cells were found to occupy locations not commonly associated with stem cells in the stomach, small intestine, colon, and hair follicles. A multipotent population of skin stem cells express Lgr6. Single Lgr5(+ve) stem cells from the small intestine and the stomach can be cultured into long-lived organoids. Further studies of these markers might reveal adult stem cell populations in additional tissues. Identification of the ligands for Lgr5 and 6 will help elucidate stem cell functions and modes of intracellular signaling.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:9481
Deposited On:04 Jan 2011 01:00
Last Modified:07 Sep 2011 17:01

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