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Genome organization influences partner selection for chromosomal rearrangements

Wijchers, P. J. and Laat de, W. (2010) Genome organization influences partner selection for chromosomal rearrangements. Trends in Genetics. ISSN 0168-9525.

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Official URL: http://dx.doi.org/10.1016/j.tig.2010.11.001

Abstract

Chromosomal rearrangements occur as a consequence of the erroneous repair of DNA double-stranded breaks, and often underlie disease. The recurrent detection of specific tumorigenic rearrangements suggests that there is a mechanism behind chromosomal partner selection involving the shape of the genome. With the advent of novel high-throughput approaches, detailed genome integrity and folding maps are becoming available. Integrating these data with knowledge of experimentally induced DNA recombination strongly suggests that partner choice in chromosomal rearrangement primarily follows the three-dimensional conformation of the genome. Local rearrangements are favored over distal and interchromosomal rearrangements. This is seen for neutral rearrangements, but not necessarily for rearrangements that drive oncogenesis. The recurrent detection of tumorigenic rearrangements probably reflects their exceptional capacity to confer growth advantage to the rare cells that contain them. The abundant presence of neutral rearrangements suggests that somatic genome variation is also common in healthy tissue.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:9484
Deposited On:04 Jan 2011 01:00
Last Modified:07 Sep 2011 17:01

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