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Hoxb8-Cre mice: A tool for brain-sparing conditional gene deletion

Witschi, R. and Johansson, T. and Morscher, G. and Scheurer, L. and Deschamps, J. and Zeilhofer, H. U. (2010) Hoxb8-Cre mice: A tool for brain-sparing conditional gene deletion. Genesis, 48, 596-602. ISSN 1526-954X.

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The spinal cord is the first site of temporal and spatial integration of nociceptive signals in the pain pathway. Neuroplastic changes occurring at this site contribute critically to various chronic pain syndromes. Gene targeting in mice has generated important insights into these processes. However, the analysis of constitutive (global) gene-deficient mice is often hampered by confounding effects arising from supraspinal sites. Here, we describe a novel Cre mouse line that expresses the Cre recombinase under the transcriptional control of the Hoxb8 gene. Within the neural axis of these mice, Hoxb8-Cre expression is found in spinal cord neurons and glial cells, and in virtually all neurons of the dorsal root ganglia, but spares the brain apart from a few cells in the spinal trigeminal nucleus. The Hoxb8-Cre mouse line should be a valuable new tool for the in vivo analysis of peripheral and spinal gene functions in pain pathways.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:9511
Deposited On:07 Feb 2011 01:00
Last Modified:07 Sep 2011 17:01

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