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Different flavors of pluripotency, molecular mechanisms, and practical implications

Buecker, C. and Geijsen, N. (2010) Different flavors of pluripotency, molecular mechanisms, and practical implications. Cell Stem Cell, 7, 559-64. ISSN 1934-5909.

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Official URL: http://dx.doi.org/10.1016/j.stem.2010.10.007

Abstract

Pluripotent stem cells (PSCs) have been classified into two distinct states: a primitive, naive LIF-dependent state represented by murine ESCs, and a primed bFGF-dependent state observed in murine and rat epiblast stem cells (EpiSCs). The vast similarities between EpiSCs and human ESCs suggest that, despite their blastocyst origin, human ESCs exist in a primed pluripotent state. Recent findings demonstrate that the naive and primed pluripotent states are interconvertible, even in human cells, and hint that growth factor-mediated Nanog expression may be an important factor regulating the balance between them.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:9512
Deposited On:07 Feb 2011 01:00
Last Modified:07 Sep 2011 17:01

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