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Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish

Geudens, I. and Herpers, R. and Hermans, K. and Segura, I. and Almodovar Ruiz de, C. and Bussmann, J. and Smet De, F. and Vandevelde, W. and Hogan, B.M. and Siekmann, A. and Claes, F. and Moore, J. and Pistocchi, A. S. and Loges, S. and Mazzone, M. and Mariggi, G. and Bruyere, F. and Cotelli, F. and Kerjaschki, D. and Noel, A. and Foidart, J. M. and Gerhardt, H. and Ny, A. and Langenberg, T. and Lawson, N. and Duckers, H.J. and Schulte-Merker, S. and Carmeliet, P. and Dewerchin, M. (2010) Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arteriosclerosis, Thrombosis and Vascular Biology, 30, 1695-702. ISSN 1079-5642.

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OBJECTIVE: To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development. METHODS AND RESULTS: In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates. CONCLUSIONS: These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:9519
Deposited On:07 Feb 2011 01:00
Last Modified:07 Sep 2011 17:01

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