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The role of small non-coding RNAs in genome stability and chromatin organization

Wolfswinkel van, J.C. and Ketting, R.F. (2010) The role of small non-coding RNAs in genome stability and chromatin organization. Journal of Cell Science, 123, 1825-39. ISSN 0021-9533.

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Official URL: http://dx.doi.org/10.1242/jcs.061713

Abstract

Small non-coding RNAs make up much of the RNA content of a cell and have the potential to regulate gene expression on many different levels. Initial discoveries in the 1990s and early 21st century focused on determining mechanisms of post-transcriptional regulation mediated by small-interfering RNAs (siRNAs) and microRNAs (miRNAs). More recent research, however, has identified new classes of RNAs and new regulatory mechanisms, expanding the known regulatory potential of small non-coding RNAs to encompass chromatin regulation. In this Commentary, we provide an overview of these chromatin-related mechanisms and speculate on the extent to which they are conserved among eukaryotes.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:9522
Deposited On:07 Feb 2011 01:00
Last Modified:07 Sep 2011 17:01

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