Lyddon, R. and Cuppen, E. and Haroutunian, V. and Siever, L. J. and Dracheva, S. (2010) No link of serotonin 2C receptor editing to serotonin transporter genotype. Neuroreport, 21, 1080-4. ISSN 0959-4965.
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Official URL: http://dx.doi.org/10.1097/WNR.0b013e32834052f0
RNA editing is a post-transcriptional process, which has the potential to alter the function of encoded proteins. In particular, serotonin 2C receptor (5-HT2cR) mRNA editing can produce 24 protein isoforms of varying functionality. Rodent studies have shown that 5-HT2cR editing is dynamically modulated in response to environmental challenges. Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Here, 5-HT2cR editing is evaluated in SERT mutant versus wild-type rats, and in humans with different SERT genotypes. Our findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels.
|Deposited On:||11 Feb 2011 01:00|
|Last Modified:||07 Sep 2011 17:01|
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