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No link of serotonin 2C receptor editing to serotonin transporter genotype

Lyddon, R. and Cuppen, E. and Haroutunian, V. and Siever, L. J. and Dracheva, S. (2010) No link of serotonin 2C receptor editing to serotonin transporter genotype. Neuroreport, 21, 1080-4. ISSN 0959-4965.

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Official URL: http://dx.doi.org/10.1097/WNR.0b013e32834052f0

Abstract

RNA editing is a post-transcriptional process, which has the potential to alter the function of encoded proteins. In particular, serotonin 2C receptor (5-HT2cR) mRNA editing can produce 24 protein isoforms of varying functionality. Rodent studies have shown that 5-HT2cR editing is dynamically modulated in response to environmental challenges. Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Here, 5-HT2cR editing is evaluated in SERT mutant versus wild-type rats, and in humans with different SERT genotypes. Our findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels.

Item Type:Article
Institutes:Hubrecht Instituut
ID Code:9535
Deposited On:11 Feb 2011 01:00
Last Modified:07 Sep 2011 17:01

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