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Items where Institute is "Hubrecht Instituut" and Year is 2006

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Number of items: 18.


Barker, N. and Clevers, J.C. (2006) Mining the Wnt pathway for cancer therapeutics. Nature reviews. Drug discovery, 5(12), 997-1014. ISSN 14741776. doi: 10.1038/nrd2154.

Carretero, J. and Medina, P.P. and Blanco, R. and Smit, L. and Tang, M. and Roncador, G. and Maestre, L. and Conde, E. and Lopez-Rios, F. and Clevers, J.C. and Sanchez-Cespedes, M. (2006) Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer. Oncogene advance online publication. ISSN 09509232. doi:10.1038/sj.onc.1209951.

Clevers, J.C. (2006) Colon cancer--understanding how NSAIDs work. The New England journal of medicine, 354(7), 761-763. ISSN 15334406. doi: 10.1056/NEJMcibr055457.

Clevers, J.C. (2006) Wnt/beta-catenin signaling in development and disease. Cell, 127(3), 469-480. ISSN 00928674. doi: 10.1016/j.cell.2006.10.018.

Clevers, J.C. and Batlle, E. (2006) EphB/EphrinB receptors and Wnt signaling in colorectal cancer. Cancer research, 66(1), 2-5. ISSN 00085472. doi: 10.1158/0008-5472.CAN-05-3849.

Giles, R.H. and Lolkema, M.P. and Snijckers, C.M. and Belderbos, M. and Groep, P. van der and Mans, D.A. and Beest, M. van and Noort, M. van and Goldschmeding, R. and Diest, P.J. van and Clevers, J.C. and Voest, E.E. (2006) Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis. Oncogene, 25(21), 3065-3070. ISSN 09509232. doi: 10.1038/sj.onc.1209330.

Haramis, A.-P.G. and Hurlstone, A. and Velden, Y. van der and Begthel, H. and Born, M. van den and Offerhaus, G.J.A. and Clevers, J.C. (2006) Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. EMBO reports, 7(4), 444-449. ISSN 1469221X. doi: 10.1038/sj.embor.7400638. PMC_URL:

Hostege, F.C.P. and Clevers, J.C. (2006) Transcription factor target practice. Cell, 124(1), 21-23. ISSN 00928674. doi: 10.1016/j.cell.2005.12.026.

Huang, Z. and Xie, H. and Ioannidis, V. and Held, W. and Clevers, J.C. and Sadim, M.S. and Sun, Z. (2006) Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway. Journal of immunology, 176(8), 4880-4887. ISSN 00221767.

Jansen, M. and Leng, W.W.J. de and Baas, A.F. and Myoshi, H. and Mathus-Vliegen, L. and Taketo, M.M. and Clevers, J.C. and Giardiello, F.M. and Offerhaus, G.J.A. (2006) Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis. Gut, 55(1), 1-5. ISSN 00175749. doi: 10.1136/gut.2005.069062.

Kloosterman, W.P. and Steiner, F.A. and Berezikov, E. and Bruijn de, E.S. and Belt van de, J. and Verheul, M. and Cuppen, E. and Plasterk, R. (2006) Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Research, 34, 2558-2569. ISSN 0305-1048.

Malliri, A. and Rygiel, T.P. and Kammen, R.A. van der and Song, J.-Y. and Engers, R. and Hurlstone, A.F.L. and Clevers, J.C. and Collard, J.G. (2006) The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. The Journal of biological chemistry, 281(1), 543-548. ISSN 00219258. doi: 10.1074/jbc.M507582200.

Markiewicz, E. and Tilgner, K. and Wetering, M. van de and Clevers, J.C. and Dorobek, M. and Haumanowa-Petrusewicz, I. and Ramaekers, F.C.S. and Broers, J.L.V. and Blankesteijn, W.M. and Salpingidou, G. and Wilson, R.G. and Ellis, J.A. and Hutchison, C.J. (2006) The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. EMBO journal, 25(14), 3275-3285. ISSN 02614189. doi: 10.1038/sj.emboj.7601230. PMC-URL:

Muncan, V. and Sansom, O.J. and Tertoolen, L. and Phesse, T.J. and Begthel, H. and Sancho, E. and Cole, A.M. and Gregorieff, A. and Alboran, I.M. de and Clevers, J.C. and Clarke, A.R. (2006) Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Molecular and cellular biology, 26(22), 8418-8426. ISSN 02707306. doi: 10.1128/MCB.00821-06. PMC_URL:

Radtke, F. and Clevers, J.C. and Riccio, O. (2006) From gut homeostasis to cancer. Current molecular medicine, 6(3), 275-289. ISSN 15665240.

Thiele, A. and Nagamine, Y. and Hauschildt, S. and Clevers, J.C. (2006) AU-rich elements and alternative splicing in the beta-catenin 3'UTR can influence the human beta-catenin mRNA stability. Experimental cell research, 312(12), 2367-2378. ISSN 00144827. doi: 10.1016/j.yexcr.2006.03.029.

Wind, J. and Hofland, J. and Preckel, B. and Hollman, M.W. and Bossuyt, P.M.M. and Gouma, D.J. and Berge Henegouwen, M.I. and Fuhring, J.W. and Dejong, C.H.C. and Dam, R.M. van and Cuesta, M.A. and Noordhuis, A. and Jong, D. de and Zalingen, E. van and Engel, A.F. and Goei, T.H. and Stoppelaar, I.E. de and Tets, W.F. van and Wagensveld, B.A. van and Swart, A. and Elsen, M.J.L.J. van den and Gerhards, M.F. and Wit, L.Th. De and Siepel, M.A.M. and Geloven, A.A.W. van and Juttmann, J.-W. and Clevers, J.C. and Bemelman, W.A. (2006) Perioperative strategy in colonic surgery; LAparoscopy and/or FAst track multimodal management versus standard care (LAFA trial). BMC Surgery, 6(16). ISSN 14712482. doi: 10.1186/1471-2482-6-16; 8 p..


Colland, F. and Barker, N. and Clevers, J.C. and Gomez, E. and Lambertus, M. and Suils, E.S. (2006) Use of specified tcf target genes to identify drugs for the treatment of cancer in particular colorectal cancer in which tcf/ss-cateini/wnt signalling plays a central role. United States Patent 20060165699;

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